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The latter test reduction was replicated by DCS, but MK-801 instead elevated test freezing. We showed that under conditions of strong fear conditioning, CBD reduced contextual fear memory expression both acutely during the extinction session as well as later at a fear retention test. injections of cannabidiol (10 mg/kg) with those of the NMDA receptor antagonist MK-801 (0.1 mg/kg) and partial agonist D-cycloserine (DCS 15 mg/kg) in order to determine the mnemonic basis of long-term fear reduction. Here, we directly compared the effects of i.p. The long-lasting impact might be mediated by an enhancement of memory extinction or an impairment of memory reconsolidation.
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3Department of Pharmacology, University of São Paulo, São Paulo, BrazilĬannabidiol (CBD) has been established to have both acute and long-lasting effects to reduce fear memory expression.2School of Biosciences, University of Nottingham, Sutton Bonington Campus, Loughborough, UK.1School of Psychology, University of Birmingham, Birmingham, UK.During assay development, the Fluidics option facilitates compound addition and cell washing to characterize potency or to determine incubation times for higher throughput fixed time point assays.Chenchen Song 1 †, Carl W. The Environmental Control Option for the ImageXpress Micro Confocal High-Content Imaging System can be configured to mimic conditions within a laboratory incubator (temperature control, gas mixture and humidity) to keep cells alive for long periods of time, making high-content screening kinetic and time lapse experiments a reality. High-resolution dual disk configuration with 60 micron confocal pinhole, 42 micron pinhole confocal and widefield modes. The ImageXpress® Micro Confocal High-Content Imaging System is a high content imaging system with confocality giving you the ultimate combination of speed, sensitivity and flexibility. It also features built-in ozone protection to minimize signal degradation. The system also enhances productivity with continuous loading from a 24-slide cassette and automatic loading of data files into Feature Extraction Software. Designed for research using microarrays, the scanner system provides a laser-induced fluorescence scanning solution designed to read microarrays printed on standard 1 inch by 3 inch glass slides.The microarray instrumentation measures the fluorescence intensity of two dyes simultaneously from labeled sample nucleic acid bound to microarrays. The Agilent SureScan Scanner provides a precise and efficient microarray scanner system for many research applications. Designed for research using microarrays, the scanner system provides a laser-induced fluorescence scanning solution designed to read microarrays printed on standard 1 inch by 3 inch glass slides.